平成28年度採択 | 微生物叢と宿主の相互作用・共生の理解と、それに基づく疾患発症のメカニズム解明

PRIME

平成28年度採択

  • 岡田 随象
  • 岡本 章玄
  • 梶谷 嶺
  • 金 倫基
  • 後藤 義幸
  • 榊原 康文
  • 坂本 光央
  • 澤 新一郎
  • 岡田 随象

    Kanai M, Tanaka T, Okada Y. Empirical estimation of genome-wide significance thresholds based on the 1000 Genomes Project data set. J Hum Genet, 2016, 61:861-866, doi: 10.1038/jhg.2016.72.
    Jing J, Pattaro C, Hoppmann A, Okada Y, CKDGen Consortium, Fox CS, Kottgen A. Combination of mouse models and genomewide association studies highlights novel genes associated with human kidney function. Kidney Int, 2016, 90:764-773, doi: 10.1016/j.kint.2016.04.004.
    van Rooij FJ, Qayyum R, Smith AV, Zhou Y, Trompet S, Tanaka T, Keller MF, Chang LC, Schmidt H, Yang ML, Chen MH, Hayes J, Johnson AD, Yanek LR, Mueller C, Lange L, Floyd JS, Ghanbari M, Zonderman AB, Jukema JW, Hofman A, van Duijn CM, Desch KC, Saba Y, Ozel AB, Snively BM, Wu JY, Schmidt R, Fornage M, Klein RJ, Fox CS, Matsuda K, Kamatani N, Wild PS, Stott DJ, Ford I, Slagboom PE, Yang J, Chu AY, Lambert AJ, Uitterlinden AG, Franco OH, Hofer E, Ginsburg D, Hu B, Keating B, Schick UM, Brody JA, Li JZ, Chen Z, Zeller T, Guralnik JM, Chasman DI, Peters LL, Kubo M, Becker DM, Li J, Eiriksdottir G, Rotter JI, Levy D, Grossmann V, Patel KV, Chen CH; BioBank Japan Project., Ridker PM, Tang H, Launer LJ, Rice KM, Li-Gao R, Ferrucci L, Evans MK, Choudhuri A, Trompouki E, Abraham BJ, Yang S, Takahashi A, Kamatani Y, Kooperberg C, Harris TB, Jee SH, Coresh J, Tsai FJ, Longo DL, Chen YT, Felix JF, Yang Q, Psaty BM, Boerwinkle E, Becker LC, Mook-Kanamori DO, Wilson JG, Gudnason V, O’Donnell CJ, Dehghan A, Cupples LA, Nalls MA, Morris AP, Okada Y, Reiner AP, Zon LI, Ganesh SK. Genome-wide trans-ethnic meta-analysis identifies seven genetic loci influencing erythrocyte traits and a role for RBPMS in erythropoiesis. Am J Hum Genet, 2017, 100:51-63, doi: 10.1016/j.ajhg.2016.11.016.
    岡田随象. ゲノム創薬. アレルギー, 2016, 65:1231-1232.
    岡田随象. 自己免疫疾患における大規模ヒトゲノム解析の現状. アレルギー, 2016, 65:921-925.
    坂上 沙央里, 岡田随象. 遺伝統計学による創薬. 腎臓内科・泌尿器科, 2016, 5:82-86.
    岸川 敏博, 岡田随象. ゲノム医療時代のバイオインフォマティクス. 医学のあゆみ, 2016, 260:332-334.
    岡田随象. 概論-「ゲノム情報」+「遺伝統計学」=「ゲノム医療」!? 実験医学, 2016, 34:2630-2635.
    Molineros JE, Yang W, Zhou XJ, Sun C, Okada Y, Zhang H, Chua KH, Lau YL, Kochi Y, Suzuki A, Yamamoto K, Ma J, Bang SY, Lee HS, Kim K, Bae SC, Zhang H, Shen N, Looger LL, Nath SK. Confirmation of five novel susceptibility loci for Systemic Lupus Erythematosus (SLE) and integrated network analysis of 82 SLE susceptibility loci. Hum Mol Genet, 2017, 26:1205-1216, doi: 10.1093/hmg/ddx026.
  • 岡本 章玄

    Saito J, Hashimoto K, Okamoto A. Nanoscale secondary ion mass spectrometry analysis of individual bacterial cells reveals feedback from extracellular electron transport to upstream reactions. Electrochemistry, 2017, 85:444-446, doi: 10.5796/electrochemistry.85.444.
  • 梶谷 嶺

  • 金 倫基

    Kim YG, Sakamoto K, Seo SU, Pickard JM, Gillilland MG 3rd, Pudlo NA, Hoostal M, Li X, Wang TD, Feehley T, Stefka AT, Schmidt TM, Martens EC, Fukuda S, Inohara N, Nagler CR, Nunez G. Neonatal acquisition of Clostridia species protects against colonization by bacterial pathogens. Science, 2017, 356:315-319, doi: 10.1126/science.aag2029.
    Sakamoto K, Kim YG, Hara H, Kamada N, Caballero-Flores G, Tolosano E, Soares MP, Puente JL, Inohara N, Nunez G. IL-22 controls iron-dependent nutritional immunity against systemic bacterial infections. Science Immunol, 2017, 2:8, doi: 10.1126/sciimmunol.aai8371.
    Kim YG. Microbiota influences vaccine and mucosal adjuvant efficacy. Immune Network, 2017, 17:20-24, doi: 10.4110/in.2017.17.1.20.
    金倫基, 長谷耕二. マイクロバイオームとアレルギー. 小児内科, 2017, 48:33-37.
  • 後藤 義幸

    後藤 義幸. SFBによる免疫細胞を介した腸管バリア形成機構の解明. 腸内細菌学雑誌, 2016, 30:159-163.
    Goto Y, Uematsu S, Kiyono H. Epithelial glycosylation in gut homeostasis and inflammation. Nat Immunol, 2016, 17:1244-1251, doi: 10.1038/ni.3587.
  • 榊原 康文

  • 坂本 光央

    坂本光央, 大熊盛也. 細菌の分類. 実験医学別冊 NGSアプリケーション 今すぐ始める! メタゲノム解析 実験プロトコール, 2016, 22-26.
    Sakamoto M, Iino T, Ohkuma M. Faecalimonas umbilicata gen. nov., sp. nov., isolated from human faeces, and reclassification of Eubacterium contortum, Eubacterium fissicatena and Clostridium oroticum as Faecalicatena contorta gen. nov., comb. nov., Faecalicatena fissicatena comb. nov. and Faecalicatena orotica com. nov. Int J Syst Evol Microbiol, 2017, 67:1219-1227, doi: 10.1099/ijsem.0.001790.
  • 澤 新一郎

    Onder L, Morbe U, Pikor N, Novkovic M, Cheng HW, Hehlgans T, Pfeffer K, Becher B, Waisman A, Rulicke T, Gommerman J, Mueller CG, Sawa S, Scandella E, Ludewig B. Lymphatic endothelial cells control initiation of lymph node organogenesis. Immunity, 47:80-92.e4, doi: 10.1016/j.immuni.2017.05.008.
    Nagashima K, Sawa S, Nitta T, Tsutsumi M, Okamura T, Penninger JM, Nakashima T, Takayanagi H. Identification of subepithelial mesenchymal cells that induce IgA and diversify gut microbiota. Nat Immunol, 2017, 18:675-682, doi: 10.1038/ni.3732.
    Okamoto K, Nakashima T, Shinohara M, Negishi-Koga T, Komatsu N, Terashima A, Sawa S, Nitta T, Takayanagi H. Osteoimmunology: the conceptual framework unifying the immune and skeletal systems. Physiol Rev, 2017, 97:1295-1349, doi: 10.1152/physrev.00036.2016.
    澤 新一郎. 新生児腸内細菌叢はどのように形成されるか? 生体の科学, 2017, 68:1-4.