天谷 雅行グループ
Yokouchi M, Atsugi T, Logtestijn MV, Tanaka RJ, Kajimura M, Suematsu M, Furuse M, Amagai M, Kubo A. Epidermal cell turnover across tight junctions based on Kelvin’s tetrakaidecahedron cell shape. Elife, 2016, 5:e19593, doi: 10.7554/eLife.19593.
横内麻里子, 久保亮治, 天谷雅行. 皮膚バリアの破綻とアトピー性皮膚炎. Medical
天谷雅行. 皮膚バリアとアトピー性疾患. 日本食品免疫学会講演記録集, 2016, 2:139–141.
川崎洋, 川上英良, 天谷雅行, 古関明彦. アトピー性皮膚炎のリバーストランスレーショナルリサーチ. 実験医学, 2017, 35:33–39.
Kato F, Nakamura M, Sugai M. The development of fluorescent protein tracing vectors for multicolor imaging of clinically isolated Staphylococcus aureus. Sci Rep, 2017, 7:2865, doi: 10.1038/s41598-017-02930-7.
大野 欽司グループ
Imai K, Kotani T, Tsuda H, Mano Y, Nakano T, Ushida T, Li H, Miki R, Sumigama S, Iwase A, Hirakawa A, Ohno K, Toyokuni S, Takeuchi H, Mizuno T, Suzumura A, Kikkawa F. Neuroprotective potential of molecular hydrogen against perinatal brain injury via suppression of activated microglia. Free Radic Biol Med, 2016, 91:154-163, doi: 10.1016/j.freeradbiomed.2015.12.015.
Hirayama M, Tsunoda M, Yamamoto M, Tsuda T, Ohno K. Serum tyrosine-to-phenylalanine ratio is low in Parkinson’s disease. J Parkinsons Dis, 2016, 6:423-431, doi: 10.3233/JPD-150736.
Muramatsu Y, Ito M, Oshima T, Kojima S, Ohno K. Hydrogen-rich water ameliorates bronchopulmonary dysplasia (BPD) in newborn rats. Pediatr Pulmonol, 2016, 51:928-935, doi: 10.1002/ppul.23386.
Lin Y, Ohkawara B, Ito M, Misawa N, Miyamoto K, Takegami Y, Masuda A, Toyokuni S, Ohno K. Molecular hydrogen suppresses activated Wnt/beta-catenin signaling. Sci Rep, 2016, 6:31986, doi: 10.1038/srep31986.
Ushida T, Kotani T, Tsuda H, Imai K, Nakano T, Hirako S, Ito Y, Li H, Mano Y, Wang J, Miki R, Yamamoto E, Iwase A, Bando YK, Hirayama M, Ohno K, Toyokuni S, Kikkawa F. Molecular hydrogen ameliorates several characteristics of preeclampsia in the Reduced Uterine Perfusion Pressure (RUPP) rat model. Free Radic Biol Med, 2016, 101:524-533, doi: 10.1016/j.freeradbiomed.2016.10.491.
Kashihara K, Nomura T, Maeda T, Tsuboi Y, Mishima T, Takigawa H, Nakashima K. Beneficial effects of ramelteon on rapid eye movement sleep behavior disorder associated with Parkinson’s disease – results of a multicenter open trial. Intern Med, 2016, 55:231-236, doi: 10.2169/internalmedicine.55.5464.
Kubo S, Hamada S, Maeda T, Uchiyama T, Hashimoto M, Nomoto N, Kano O, Takahashi T, Terashi H, Takahashi T, Hatano T, Hasegawa T, Baba Y, Sengoku R, Watanabe H, Kadowaki T, Inoue M, Kaneko S, Shimura H, Nagayama H. A Japanese multicenter survey characterizing pain in Parkinson’s disease. J Neurol Sci, 2016, 365:162-166, doi: 10.1016/j.jns.2016.04.015.
Yoritaka A, Abe T, Ohtsuka C, Maeda T, Hirayama M, Watanabe H, Saiki H, Oyama G, Fukae J, Shimo Y, Hatano T, Kawajiri S, Okuma Y, Machida Y, Miwa H, Suzuki C, Kazama A, Tomiyama M, Kihara T, Hirasawa M, Shimura H, Hattori N. A randomized double-blind multi-center trial of hydrogen water for Parkinson’s disease: protocol and baseline characteristics. BMC Neurol, 2016, 16:66, doi: 10.1186/s12883-016-0589-0.
Umemoto G, Fujioka S, Yanamoto S, Fukae J, Tsuboi Y. A case of sudden deterioration in Parkinson disease. Neurology, 2016, 87:1422, doi: 10.1212/WNL.0000000000003163.
Onozawa R, Tsugawa J, Tsuboi Y, Fukae J, Mishima T, Fujioka S. The impact of early morning off in Parkinson’s disease on patient quality of life and caregiver burden. J Neurol Sci, 2016, 364:1-5, doi: 10.1016/j.jns.2016.02.066.
Miyake Y, Tanaka K, Fukushima W, Kiyohara C, Sasaki S, Tsuboi Y, Oeda T, Shimada H, Kawamura N, Sakae N, Fukuyama H, Hirota Y, Nagai M, Nakamura Y, Fukuoka Kinki Parkinson’s Disease Study Group. PARK16 polymorphisms, interaction with smoking, and sporadic Parkinson’s disease in Japan. J Neurol Sci, 2016, 362:47-52, doi: 10.1016/j.jns.2016.01.021.
柏原健一. パーキンソン病における認知障害の早期診断法. Dementia Japan, 2016, 30:213-222.
柏原健一, 北山通朗, 濱口敏和. ダットスキャン早期像の臨床的意義―5 症例の検討. 運動障害, 2016, 26:27-32.
柏原健一, 濱口敏和, 北村通朗. チェックリストを用いた Parkinson 病患者の症状把握. 神経内科, 2016, 84:88-93.
柏原健一. パーキンソン病診断における自律神経症状の意義. 自律神経, 2016, 53:111-119.
Hasegawa S, Ito M, Fukami M, Hashimoto M, Hirayama M, Ohno K. Molecular hydrogen alleviates motor deficits and muscle degeneration in mdx mice. Redox Rep, 2017, 22:26-34, doi: 10.1080/13510002.2015.1135580.
金井 隆典グループ
Hosoe N, Matsukawa S, Kanno Y, Naganuma M, Imaeda H, Ida Y, Tsuchiya Y, Hibi T, Ogata H, Kanai T. Cross-sectional small intestinal surveillance of maintenance hemodialysis patients using video capsule endoscopy: SCHEMA study. Endosc Int Open, 2016, 4:E589-E596, doi: 10.1055/s-0042-105203.
Fujii M, Shimokawa M, Date S, Takano A, Matano M, Nanki K, Ohta Y, Toshimitsu K, Nakazato Y, Kawasaki K, Uraoka T, Watanabe T, Kanai T, Sato T. A colorectal tumor organoid library demonstrates progressive loss of niche factor requirements during tumorigenesis. Cell Stem Cell, 2016, 18:827-838, doi: 10.1016/j.stem.2016.04.003.
Suzuki H, Hisamatsu T, Chiba S, Mori K, Kitazume MT, Shimamura K, Nakamoto N, Matsuoka K, Ebinuma H, Naganuma M, Kanai T. Glycolytic pathway affects differentiation of human monocytes to regulatory macrophages. Immunol Lett, 2016, 176:18-27, doi: 10.1016/j.imlet.2016.05.009.
Arai M, Naganuma M, Sugimoto S, Kiyohara H, Ono K, Mori K, Saigusa K, Nanki K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Matsuoka K, Inoue N, Ogata H, Iwao Y, Kanai T. The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) is useful to predict medium to long-term prognosis in ulcerative colitis patients with clinical remission. J Crohns Colitis, 2016, 10:1303-1309, doi: 10.1093/ecco-jcc/jjw104.
Sugimoto S, Naganuma M, Kanai T. Indole compounds may be promising medicines for ulcerative colitis. J Gastroenterol, 2016, 51:853-861, doi: 10.1007/s00535-016-1220-2.
Saito Y, Nakaoka T, Sakai K, Muramatsu T, Toshimitsu K, Kimura M, Kanai T, Sato T, Saito H. Inhibition of DNA methylation suppresses intestinal tumor organoids by inducing an anti-viral response. Sci Rep, 2016, 6:25311, doi: 10.1038/srep25311.
Kawasaki K, Hamamoto Y, Fukada J, Adachi M, Sasaki H, Takaishi H, Yoshida K, Kanai T. Fatal hemorrhage in a patient with advanced soft tissue sarcoma following radiation and pazopanib treatment. Oncol Lett, 2016, 11:2408-2410, doi: 10.3892/ol.2016.4246.
Saigusa K, Matsuoka K, Sugimoto S, Arai M, Kiyohara H, Takeshita K, Mizuno S, Mori K, Nanki K, Takeshita T, Nakazato Y, Yajima T, Naganuma M, Hisamatsu T, Ogata H, Iwao Y, Kanai T. Ulcerative colitis endoscopic index of severity is associated with long-term prognosis in ulcerative colitis patients treated with infliximab. Dig Endosc, 2016, 28:665-670, doi: 10.1111/den.12655.
Sugimoto S, Naganuma M, Kiyohara H, Arai M, Ono K, Mori K, Saigusa K, Nanki K, Takeshita K, Takeshita T, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hisamatsu T, Inoue N, Ogata H, Iwao Y, Kanai T. Clinical efficacy and safety of oral Qing-Dai in patients with ulcerative colitis: A single-center open-label prospective study. Digestion, 2016, 93:193-201, doi: 10.1159/000444217.
Kawasaki K, Hamamoto Y, Adachi M, Kanai T, Takaishi H. Early tumor cavitation with regorafenib in metastatic colorectal cancer. Oncol Lett, 2016, 11:231-233, doi: 10.3892/ol.2015.3905.
Imaeda H, Nakajima K, Hosoe N, Nakahara M, Zushi S, Kato M, Kashiwagi K, Matsumoto Y, Kimura K, Nakamura R, Wada N, Tsujii M, Yahagi N, Hibi T, Kanai T, Takehara T, Ogata H. Percutaneous endoscopic gastrostomy under steady pressure automatically controlled endoscopy. World J Gastrointest Endosc, 2016, 8:186-191, doi: 10.4253/wjge.v8.i3.186.
Shinoda M, Ebinuma H, Itano O, Yamagishi Y, Obara H, Kitago M, Nakamoto N, Hibi T, Yagi H, Abe Y, Matsubara K, Chu PS, Wakayama Y, Taniki N, Yamaguchi A, Amemiya R, Miyake R, Mizota T, Kanai T, Kitagawa Y. Simeprevir/pegylated interferon/ribavirin triple therapy for recurrent hepatitis C after living donor liver transplantation. Hepatol Res, 2016, 46:1118-1128, doi: 10.1111/hepr.12666.
Naganuma M, Hisamatsu T, Matsuoka K, Kiyohara H, Arai M, Sugimoto S, Mori K, Nanki K, Ohno K, Mutaguchi M, Mizuno S, Bessho R, Nakazato Y, Hosoe N, Inoue N, Iwao Y, Ogata H, Kanai T. Endoscopic severity predicts long-term prognosis in Crohn’s disease patients with clinical remission. Digestion, 2016, 93:66-71, doi: 10.1159/000441767.
Uraoka T, Ochiai Y, Fujimoto A, Goto O, Kawahara Y, Kobayashi N, Kanai T, Matsuda S, Kitagawa Y, Yahagi N. A novel fully synthetic and self-assembled peptide solution for endoscopic submucosal dissection-induced ulcer in the stomach. Gastrointest Endosc, 2016, 83:1259-1264, doi: 10.1016/j.gie.2015.11.015.
Naganuma M, Okuda S, Hisamatsu T, Matsuoka K, Mori K, Hosoe N, Nakazato Y, Ogata H, Kanai T. Findings of ulceration and severe stricture on MRE can predict prognosis of Crohn’s disease in patients treated with anti-TNF treatment. Abdom Radiol (NY), 2016, 42:141-151, doi: 10.1007/s00261-016-0878-5.
Mori H, Suzuki H, Matsuzaki J, Tsugawa H, Fukuhara S, Miyoshi S, Hirata K, Seino T, Matsushita M, Nishizawa T, Masaoka T, Kanai T. Rifabutin-based 10-day and 14-day triple therapy as a third- line and fourth-line regimen for Helicobacter pylori eradication: A pilot study. United European Gastroenterol J, 2016, 4:380-387, doi: 10.1177/2050640615618043.
Kawasaki S, Itoi T, Iwasaki E, Hosoe N, Ogata H, Kanai T. Successful pancreatic duct stent placement for recurrent pancreatitis in a patient with polysplenia with agenesis of the dorsal pancreas and Peutz-Jeghers syndrome. Intern Med, 2016, 55:1743-1746, doi: 10.2169/internalmedicine.55.6128.
Blokzijl F, de Ligt J, Jager M, Sasselli V, Roerink S, Sasaki N, Huch M, Boymans S, Kuijk E, Prins P, Nijman IJ, Martincorena I, Mokry M, Wiegerinck CL, Middendorp S, Sato T, Schwank G, Nieuwenhuis EE, Verstegen MM, van der Laan LJ, de Jonge J, IJzermans JN, Vries RG, van de Wetering M, Stratton MR, Clevers H, Cuppen E, van Boxtel R. Tissue-specific mutation accumulation in human adult stem cells during life. Nature, 2016, 538:260-264, doi: 10.1038/nature19768.
Sasaki N, Sachs N, Wiebrands K, Ellenbroek SI, Fumagalli A, Lyubimova A, Begthel H, van den Born M, van Es JH, Karthaus WR, Li VS, Lopez-Iglesias C, Peters PJ, van Rheenen J, van Oudenaarden A, Clevers H. Reg4+deep crypt secretory cells function as epithelial niche for Lgr5+stem cells in colon. Proc Natl Acad Sci USA, 2016, 113:E5399-E5407, doi: 10.1073/pnas.1607327113.
南木康作, 金井隆典. 【腸内細菌から IBD の病態を探る】 腸内フローライノベーションの現況と未来. IBD Research, 2016, 1:36-41.
別所理恵子, 金井隆典. クローン病. 診療ガイドライン UP-TODATE 2016→2017, 2016, 11:260-266.
正岡建洋, 山根剛, 金井隆典. 注目の最新治療 糞便移植と消化器疾患. ASAHI medical, 2016, 3:18-19.
金井隆典.【難治性疾患実用化研究 自己免疫疾患】難治性クローン病に対する神経難病治療薬OCH-NCNP の有用性および安全性の検証. 臨床評価, 2016, 2:489-492.
新井万里, 水野慎大, 金井隆典.【シリーズ 腸内細菌叢】炎症性腸疾患における糞便微生物移植法の過去・現在・未来. Modern Media, 2016, 3:69-74.
細江直樹, 金井隆典. 潰瘍性大腸炎に対する最新の内視鏡診断 拡大内視鏡、超拡大内視鏡、カプセル内視鏡 医学の歩み. 炎症性腸疾患のいま, 2016, 10:1048-1052.
今枝博之, 細江直樹, 山岡稔, 芦谷啓吾, 大庫秀樹, 柏木和弘, 中元秀友, 緒方晴彦, 金井隆典. 自家蛍光内視鏡の現況. Gastroenterological Endoscopy, 2016, 4:957-969.
正岡建洋, 山根剛, 金井隆典.【糞便微生物移植(FMT)】機能性消化管疾患に対する糞便微生物移植. G.I.Research, 2016, 24:31-35.
清原裕貴, 水野慎大, 金井隆典.【炎症性腸疾患のいま】疫学と研究の進展 炎症性腸疾患と腸内細菌叢のかかわり. 医学のあゆみ, 2016, 256:1015-1020.
堀江義則, 海老沼浩利, 菊池真大, 志波俊輔, 中本伸宏, 金井隆典. 本邦におけるアルコール性肝炎の現状 -全国アンケート調査報告(2012 年度)-. 肝臓, 2016, 4:171-177.
金井隆典, 南木康作. ヒトでも始まった糞便微生物移植の実際. 日本臨床腸内微生物学会誌, 2016, 1:4-9.
長沼誠, 金井隆典.【炎症性腸疾患に対するアフェレシスの進歩と工夫】潰瘍性大腸炎に対する血球成分吸着除去療法の長期予後. 日本アフェレシス学会雑誌, 2016, 2:101-105.
南木康作, 金井隆典.【腸内細菌から IBD の病態を探る!】腸内フローライノベーションの現状と未来. IBD Research, 2016, 1:36-41.
細江直樹, 金井隆典.【炎症性腸疾患 新しい考えかたに基づく実地診療の実践】炎症性腸疾患に対する大腸カプセル内視鏡の現状と未来. Medical Practice, 2016, 5:771-772.
長沼誠, 緒方晴彦, 金井隆典.【クローン病治療の最前線】術後クローン病の治療戦略. Intestine, 2016, 2:173-179.
菊池真大, 梅田瑠美子, 鶴谷康太, 塩沢宏和, 松嶋成志, 阿部圭一郎, 菊池美穂, 高橋正彦, 山岸由幸, 西澤泰弘, 堀江義則, 金井隆典. 非侵襲的肝脂肪測定 Controlled Attenuation Parameter(CAP) によるアルコール性肝障害患者の鑑別. 日本アルコール・薬物医学会雑誌, 2016, 5:235.
中本伸宏, 褚伯松, 海老沼浩利, 齋藤英胤, 金井隆典.【免疫寛容と免疫抑制】急性肝障害・肝線維化病態における CCR9/CCL25 の役割. 臨床免疫・アレルギー科, 2016, 4:304-309.
細江直樹, 緒方晴彦, 金井隆典.【《症例から学ぶ》内科疾患の診断・治療ピットフォール】(第 2 章)消化器 消化管出血. 内科, 2016, 4:614-615.
清原裕貴, 水野慎大, 長沼誠, 金井隆典.【潰瘍性大腸炎-診断と治療の最前線-】潰瘍性大腸炎内科的治療の最前線. 日本消化器病学会雑誌, 2016, 3:413-425.
佐々木伸雄. 大腸幹細胞特異的ニッシェによる粘膜上皮の恒常性維持機構. 臨床免疫・アレルギー科, 2016, 66:407-412.
佐々木伸雄, 佐藤俊朗. 腸管上皮オルガノイド-幹細胞制御機構の理解と腸管上皮オルガノイド培養法. 実験医学, 2016, 34:90-96.
竹田 潔グループ
Barman S, Kayama H, Okuzaki D, Ogino T, Osawa H, Matsuno H, Mizushima T, Mori M, Nishimura J, Takeda K. Identification of a human intestinal myeloid cell subset that regulates the gut homeostasis. Int Immunol, 2016, 28:533-545, doi: 10.1093/intimm/dxw034.
Okumura R, Takeda K. Maintenance of gut homeostasis by the mucosal immune system. Proc Jpn Acad Ser B Phys Biol Sci, 2016, 92:423-435, doi: 10.2183/pjab.92.423.
Maeda Y, Kurakawa T, Umemoto E, Motooka D, Ito Y, Gotoh K, Hirota K, Matsushita M, Furuta Y, Narazaki M, Sakaguchi N, Kayama H, Nakamura S, Iida T, Saeki Y, Kumanogoh A, Sakaguchi S, Takeda K. Dysbiosis contributes to arthritis development via activation of autoreactive T cells in the intestine. Arthritis Rheum, 2016, 68:2646-2661, doi: 10.1002/art.39783.
Bag S, Saha B, Mehta O, Anbumani D, Kumar N, Dayal M, Pant A, Kumar P, Saxena S, Allin KH, Hansen T, Arumugam M, Vestergaard H, Pedersen O, Pereira V, Abraham P, Tripathi R, Wadhwa N, Bhatnagar S, Prakash VG, Radha V, Anjana RM, Mohan V, Takeda K, Kurakawa T, Nair GB, Das B. An improved method for high quality metagenomics DNA extraction from human and environmental samples. Sci Rep, 2016, 6:26775, doi: 10.1038/srep26775.
Tsai SH, Takeda K. Regulation of allergic inflammation by the ectoenzyme E-NPP3 (CD203c) on basophils and mast cells. Semin Immunopathol, 2016, 38:571-579, doi: 10.1007/s00281-016-0564-2.
Yang JY, Lee YS, Kim Y, Lee SH, Ryu S, Fukuda S, Hase K, Yang CS, Lim HS, Kim MS, Kim HM, Ahn SH, Kwon BE, Ko HJ, Kweon MN. Gut commensal Bacteroides acidifaciens prevents obesity and improves insulin sensitivity in mice. Mucosal Immunol, 2016, 10:104-116, doi: 10.1038/mi.2016.42.
Ohashi W, Kimura S, Iwanaga T, Furusawa Y, Irie T, Izumi H, Watanabe T, Hijikata A, Hara T, Ohara O, Koseki H, Sato T, Robine S, Mori H, Hattori Y, Watarai H, Mishima K, Ohno H, Hase K, Fukada T. Zinc transporter SLC39A7/ZIP7 promotes intestinal epithelial self-renewal by resolving ER stress. PLoS Genet, 2016, 12:e1006349, doi: 10.1371/journal.pgen.1006349.
Kimura S, Yamashita M, Yamakami-Kimura M, Sato Y, Yamagata A, Kobashigawa Y, Inagaki F, Amada T, Hase K, Iwanaga T, Ohno H, Fukai S. Distinct roles for the N- and C-terminal regions of M-Sec in plasma membrane deformation during tunneling nanotube formation. Sci Rep, 2016, 6:33548, doi: 10.1038/srep33548.
Nagai M, Obata Y, Takahashi D, Hase K. Fine-tuning of the mucosal barrier and metabolic systems using the diet-microbial metabolite axis. Int Immunopharmacol, 2016, 37:79-86, doi: 10.1016/j.intimp.2016.04.001.
Yamada T, Takahashi D, Hase K. The diet-microbiota-metabolite axis regulates the host physiology. J Biochem, 2016, 160:1-10, doi: 10.1093/jb/mvw022.
Shiraishi E, Iijima H, Shinzaki S, Nakajima S, Inoue T, Hiyama S, Kawai S, Araki M, Yamaguchi T, Hayashi Y, Fujii H, Nishida T, Tsujii M, Takehara T. Vitamin K deficiency leads to exacerbation of murine dextran sulfate sodium-induced colitis. J Gastroenterol, 2016, 51:346-356, doi: 10.1007/s00535-015-1112-x.
Shinzaki S, Ishii M, Fujii H, Iijima H, Wakamatsu K, Kawai S, Shiraishi E, Hiyama S, Inoue T, Hayashi Y, Kuwahara R, Takamatsu S, Kamada Y, Morii E, Tsujii M, Takehara T, Miyoshi E. N-Acetylglucosaminyltransferase V exacerbates murine colitis with macrophage dysfunction and enhances colitic tumorigenesis. J Gastroenterol, 2016, 51:357-369, doi: 10.1007/s00535-015-1119-3.
Okumura R, Kurakawa T, Nakano T, Kayama H, Kinoshita M, Motooka D, Gotoh K, Kimura T, Kamiyama N, Kusu T, Ueda Y, Wu H, Iijima H, Barman S, Osawa H, Matsuno H, Nishimura J, Ohba Y, Nakamura S, Iida T, Yamamoto M, Umemoto E, Sano K, Takeda K. Lypd8 promotes the segregation of flagellated microbiota and colonic epithelia. Nature, 2016, 532:117-121, doi: 10.1038/nature17406.
Hiyama S, Iijima H, Kawai S, Mukai A, Shiraishi E, Iwatani S, Yamaguchi T, Araki M, Hayashi Y, Shinzaki S, Mizushima T, Tsujii M, Takehara T. Narrow-band imaging with magnifying endoscopy for Peyer’s patches is useful in predicting the recurrence of remissive patients with ulcerative colitis. Intest Res, 2016, 14:314-321, doi: 10.5217/ir.2016.14.4.314.
Hayashi Y, Tsujii M, Kodama T, Akasaka T, Kondo J, Hikita H, Inoue T, Tsujii Y, Maekawa A, Yoshii S, Shinzaki S, Watabe K, Tomita Y, Inoue M, Tatsumi T, Iijima H, Takehara T. p53 functional deficiency in human colon cancer cells promotes fibroblast-mediated angiogenesis and tumor growth. Carcinogenesis, 2016, 37:972-984, doi: 10.1093/carcin/bgw085.
Fujii H, Shinzaki S, Iijima H, Wakamatsu K, Iwamoto C, Sobajima T, Kuwahara R, Hiyama S, Hayashi Y, Takamatsu S, Uozumi N, Kamada Y, Tsujii M, Taniguchi N, Takehara T, Miyoshi E. Core fucosylation on T cells, required for activation of T-cell receptor signaling and induction of colitis in mice, Is increased in patients with inflammatory bowel disease. Gastroenterology, 2016, 150:1620-1632, doi: 10.1053/j.gastro.2016.03.002.
Furuta Y, Tsai SH, Kinoshita M, Fujimoto K, Okumura R, Umemoto E, Kurashima Y, Kiyono H, Kayama H, Takeda K. E-NPP3 controls plasmacytoid dendritic cell numbers in the small intestine. PLOS ONE, 2017, 12:e0172509, doi: 10.1371/journal.pone.0172509.
Motooka D, Fujimoto K, Tanaka R, Yaguchi T, Gotoh K, Maeda Y, Furuta Y, Kurakawa T, Goto N, Yasunaga T, Narazaki M, Kumanogoh A, Horii T, Iida T, Takeda K, Nakamura S. Fungal ITS1 deep-sequencing strategies to reconstruct the composition of a 26-species community and evaluation of the gut mycobiota of healthy Japanese individuals. Front Microbiol, 2017, 8:238, doi: 10.3389/fmicb.2017.00238.
Okumura R, Takeda K. Roles of intestinal epithelial cells in the maintenance of gut homeostasis. Exp Mol Med, 2017, 49:e338, doi: 10.1038/emm.2017.20.
Yokota M, Tamachi T, Yokoyama Y, Maezawa Y, Takatori H, Suto A, Suzuki K, Hirose K, Takeda K, Nakajima H. IκBNS induces Muc5ac expression in epithelial cells and causes airway hyper-responsiveness in murine asthma models. Allergy, 2017, 72:1043-1053, doi: 10.1111/all.13079.
Kitada S, Kayama H, Okuzaki D, Koga R, Kobayashi M, Arima Y, Kumanogoh A, Murakami M, Ikawa M, Takeda K. BATF2 inhibits immunopathological Th17 responses by suppressing Il23a expression during Trypanosoma cruzi infection. J Exp Med, 2017, 214:1313-1331, doi: 10.1084/jem.20161076.
Fujimoto K, Kinoshita M, Tamura A, Tanaka H, Okuzaki D, Shimada Y, Kayama H, Okumura R, Furuta Y, Narazaki M, Hatakeyama S, Ikawa M, Tsuchiya K, Watanabe M, Kumanogoh A, Tsukita S, Takeda K. Regulation of intestinal homeostasis by the ulcerative colitis-associated gene RNF186. Mucosal Immunol, 2017, 10:446-445, doi: 10.1038/mi.2016.58.
Shinzaki S, Matsuoka K, Iijima H, Mizuno S, Serada S, Fujimoto M, Arai N, Koyama N, Morii E, Watanabe M, Hibi T, Kanai T, Takehara T, Naka T. Leucine-rich alpha-2 glycoprotein is a serum biomarker of mucosal healing in ulcerative colitis. J Crohn’s Colitis, 2017, 11:84-91, doi: 10.1093/ecco-jcc/jjw132.
Kawai S, Iijima H, Shinzaki S, Hiyama S, Yamaguchi T, Araki M, Iwatani S, Shiraishi E, Mukai A, Inoue T, Hayashi Y, Tsujii M, Motooka D, Nakamura S, Iida T, Takehara T. Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation. J Gastroenterol, 2017, 52:904-919, doi: 10.1007/s00535-016-1292-z.
Araki M, Shinzaki S, Yamada T, Arimitsu S, Komori M, Shibukawa N, Mukai A, Nakajima S, Kinoshita K, Kitamura S, Murayama Y, Ogawa H, Yasunaga Y, Oshita M, Fukui H, Masuda E, Tsujii M, Hiyama S, Inoue T, Iijima H, Takehara T. Age at onset is associated with the seasonal pattern of onset and exacerbation in inflammatory bowel disease. J Gastroenterol, 2017, 52:1149-1157, doi: 10.1007/s00535-017-1313-6.
西川 博嘉グループ
Saito T, Nishikawa H, Wada H, Nagano Y, Sugiyama D, Atarashi K, Maeda Y, Hamaguchi M, Ohkura N, Sato E, Nagase H, Nishimura J, Yamamoto H, Takiguchi S, Tanoue T, Suda W, Morita H, Hattori M, Honda K, Mori M, Doki Y, Sakaguchi S. Two FOXP3+CD4+ T-cell subpopulations distinctly control the prognosis of colorectal cancers. Nat Med, 2016, 22:679-684, doi: 10.1038/nm.4086.
Okubo K, Wada H, Tanaka A, Eguchi H, Hamaguchi M, Tomokuni A, Tomimaru Y, Asaoka T, Hama N, Kawamoto K, Kobayashi S, Marubashi S, Nagano H, Sakaguchi N, Nishikawa H, Doki Y, Mori M, Sakaguchi S. Identification of novel and noninvasive biomarkers of acute cellular rejection after liver transplantation by protein microarray. Transplant Direct, 2016, 2:e118, doi: 10.1097/TXD.0000000000000630.
Kakihana K, Fujioka Y, Suda W, Najima Y, Kuwata G, Sasajima S, Mimura I, Morita H, Sugiyama D, Nishikawa H, Hattori M, Hino Y, Ikegawa S, Yamamoto K, Toya T, Doki N, Koizumi K, Honda K, Ohashi K. Fecal microbiota transplantation for patients with steroid-resistant/dependent acute graft-versus-host disease of the gut. Blood, 2016, 128:2083-2088, doi: 10.1182/blood-2016-05-717652.
Haseda F, Imagawa A, Nishikawa H, Mitsui S, Tsutsumi C, Fujisawa R, Sano H, Murase-Mishiba Y, Terasaki J, Sakaguchi S, Hanafusa T. Antibody to CMRF35-like molecule 2, CD300e a novel biomarker detected in patients with fulminant type 1 diabetes. PLOS ONE, 2016, 11:e0160576, doi: 10.1371/journal.pone.0160576.
Ureshino H, Shindo T, Nishikawa H, Watanabe N, Watanabe E, Satoh N, Kitaura K, Kitamura H, Doi K, Nagase K, Kimura H, Samukawa M, Kusunoki S, Miyahara M, Shin-I T, Suzuki R, Sakaguchi S, Kimura S. Effector regulatory T cells reflect the equilibrium between antitumor immunity and autoimmunity in adult T-cell leukemia. Cancer Immunol Res, 2016, 4:644-649, doi: 10.1158/2326-6066.CIR-15-0303.
Takeuchi Y, Nishikawa H. Roles of regulatory T cells in cancer immunity. Int Immunol, 2016, 28:401-409, doi: 10.1093/intimm/dxw025.
Shimazu Y, Shimazu Y, Hishizawa M, Hamaguchi M, Nagai Y, Sugino N, Fujii S, Kawahara M, Kadowaki N, Nishikawa H, Sakaguchi S, Takaori-Kondo A. Hypomethylation of the Treg-specific demethylated region in FOXP3 is a hallmark of the regulatory T-cell subtype in adult T-cell leukemia. Cancer Immunol Res, 2016, 4:136-145, doi: 10.1158/2326-6066.CIR-15-0148.
Hayakawa Y, Kawada M, Nishikawa H, Ochiya T, Saya H, Seimiya H, Yao R, Hayashi M, Kai C, Matsuda A, Naoe T, Ohtsu A, Okazaki T, Saji H, Sata M, Sugimura H, Sugiyama Y, Toi M, Irimura T. Report on the use of non-clinical studies in the regulatory evaluation of oncology drugs. Cancer Sci, 2016, 107:189-202, doi: 10.1111/cas.12857.
Yasuda T, Tsuzuki S, Kawazu M, Hayakawa F, Kojima S, Ueno T, Imoto N, Kohsaka S, Kunita A, Doi K, Sakura T, Yujiri T, Kondo E, Fujimaki K, Ueda Y, Aoyama Y, Ohtake S, Takita J, Sai E, Taniwaki M, Kurokawa M, Morishita S, Fukayama M, Kiyoi H, Miyazaki Y, Naoe T, Mano H. Recurrent DUX4 fusions in B cell acute lymphoblastic leukemia of adolescents and young adults. Nat Genet, 2016, 48:569-574, doi: 10.1038/ng.3535.
Ando M, Kawazu M, Ueno T, Koinuma D, Ando K, Koya J, Kataoka K, Yasuda T, Yamaguchi H, Fukumura K, Yamato A, Soda M, Sai E, Yamashita Y, Asakage T, Miyazaki Y, Kurokawa M, Miyazono K, Nimer SD, Yamasoba T, Mano H. Mutational landscape and antiproliferative functions of ELF transcription factors in human cancer. Cancer Res, 2016, 76:1814-1824.
Fukumura K, Kawazu M, Kojima S, Ueno T, Sai E, Soda M, Ueda H, Yasuda T, Yamaguchi H, Lee J, Shishido-Hara Y, Sasaki A, Shirahata M, Mishima K, Ichimura K, Mukasa A, Narita Y, Saito N, Aburatani H, Nishikawa R, Nagane M, Mano H. Genomic characterization of primary central nervous system lymphoma. Acta Neuropathol, 2016, 131:865-875, doi: 10.1007/s00401-016-1536-2.
西川博嘉. 免疫チェックポイント阻害剤の臨床導入に伴うがん免疫療法の今後の展望. BIO Clinica, 2016, 31:16-17.
坂井千香, 西川博嘉. 腫瘍免疫応答と制御性T細胞. 実験医学増刊, 2016, 34:1884-1889.
竹内美子, 西川博嘉. 免疫調節受容体を標的としたがん免疫療法ー免疫刺激分子および免疫抑制分子に対する抗体療法ー. 医学のあゆみ, 2016, 258:97-105.
藤岡優樹, 西川博嘉. 免疫チェックポイントの基礎. 多発性骨髄腫 Updating, 2016, 9:111-119.
杉山大介, 西川博嘉. がん微小環境における免疫抑制機構. 医学のあゆみ, 2016, 258:445-450.
Danbee Ha, 竹内美子, 西川博嘉. 癌免疫療法の作用機序ー免疫チェックポイント阻害療法など 4 療法への取り組み. 日本医事新報, 2016, 26-35.
杉山栄里, 西川博嘉. 免疫チェックポイント阻害薬の基礎. Pharma Medica, 2016, 34:23-27.
坂井千香, 西川博嘉. 腫瘍における制御性T細胞の抑制. 臨床免疫・アレルギー科, 2016, 66:199-204.
藤岡優樹, 西川博嘉. がん免疫療法の基礎. 臨床血液, 2016, 57:2346-2354.
杉山大介, 西川博嘉. がん免疫における制御性T細胞. 腫瘍内科, 2016, 17:94-97.
藤岡優樹, 西川博嘉. 免疫チェックポイント阻害剤と他の免疫療法との併用の可能性. Pharma stage, 2016, 15:39-48.
Nagase H, Takeoka T, Urakawa S, Morimoto-Okazawa A, Kawashima A, Iwahori K, Takiguchi S, Nishikawa H, Sato E, Sakaguchi S, Mori M, Doki Y, Wada H. ICOS+ Foxp3+TILs in gastric cancer are prognostic markers and effector regulatory T cells associated with Helicobacter pylori. Int J Cancer, 2017, 140:686-695, doi: 10.1002/ijc.30475.
Takeoka T, Nagase H, Kurose K, Ohue Y, Yamasaki M, Takiguchi S, Sato E, Isobe M, Kanazawa T, Matsumoto M, Iwahori K, Kawashima A, Morimoto-Okazawa A, Nishikawa H, Oka M, Pan L, Venhaus R, Nakayama E, Mori M, Doki Y, Wada H. NY-ESO-1 protein cancer vaccine with poly-ICLC and OK-432: rapid and strong induction of NY-ESO-1-specific immune responses by poly-ICLC. J Immunother, 2017, 40:140-147, doi: 10.1097/CJI.0000000000000162.
Hamano Y, Kida H, Ihara S, Murakami A, Yanagawa M, Ueda K, Honda O, Tripathi LP, Arai T, Hirose M, Hamasaki T, Yano Y, Kimura T, Kato Y, Takamatsu H, Otsuka T, Minami T, Hirata H, Inoue K, Nagatomo I, Takeda Y, Mori M, Nishikawa H, Mizuguchi K, Kijima T, Kitaichi M, Tomiyama N, Inoue Y, Kumanogoh A. Classification of idiopathic interstitial pneumonias using anti-myxovirus resistance-protein 1 autoantibody. Sci Rep, 2017, 7:43201, doi: 10.1038/srep43201.
Nakamura T, Yamashita S, Fukumura K, Nakabayashi J, Tanaka K, Tamura K, Tateishi K, Kinoshita M, Fukushima S, Takami H, Fukuoka K, Yamazaki K, Matsushita Y, Ohno M, Miyakita Y, Shibui S, Kubo A, Shuto T, Kocialkowski S, Yamanaka S, Mukasa A, Sasayama T, Mishima K, Maehara T, Kawahara N, Nagane M, Narita Y, Mano H, Ushijima T, Ichimura K. Genome-wide DNA methylation profiling identifies primary central nervous system lymphoma as a distinct entity different from systemic diffuse large B-cell lymphoma. Acta Neuropathol, 2017, 133:321-324, doi: 10.1007/s00401-016-1664-8.
Kawai S, Iijima H, Shinzaki S, Hiyama S, Yamaguchi T, Araki M, Iwatani S, Shiraishi E, Mukai A, Inoue T, Hayashi Y, Tsujii M, Motooka D, Nakamura S, Iida T, Takehara T. Indigo Naturalis ameliorates murine dextran sodium sulfate-induced colitis via aryl hydrocarbon receptor activation. J Gastroenterol, 2017, 52:904-919, doi: 10.1007/s00535-016-1292-z.
Motooka D, Fujimoto K, Tanaka R, Yaguchi T, Gotoh K, Maeda Y, Furuta Y, Kurakawa T, Goto N, Yasunaga T, Narazaki M, Kumanogoh A, Horii T, Iida T, Takeda K, Nakamura S. Fungal ITS1 deep-sequencing strategies to reconstruct the composition of a 26-species community and evaluation of the gut mycobiota of healthy Japanese individuals. Front Microbiol, 2017, 8:238, doi: 10.3389/fmicb.2017.00238.
